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portions of bedbug genome sequenced

(4 posts)
  1. bait

    senior member
    Joined: Jul '08
    Posts: 559


    Posted 8 years ago
    Tue Jan 25 2011 0:31:23

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    There's new research on C. lectularius DNA by Ohio State Univ., Transcriptomics of the Bed Bug" (Bai, Mamidala, Rajarapu, Jones, Mittapalli)

    Published online by PLoS One, here's the address:

    "this is the first study to elucidate the genetic makeup of C. lectularius."

    To simplify, I found a quote from the Wall Street Journal, "bedbugs may have boosted their natural defenses by generating higher levels of enzymes that can cleanse them of poisons."


  2. bed-bugscouk

    Joined: Apr '07
    Posts: 18,164


    Posted 8 years ago
    Tue Jan 25 2011 8:14:27

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    Hi Bait,

    Sorry stuck in pedant mode today.

    Transcriptomics is the science of expressed parts of the DNA, the messenger sequences that make things happens for want of a better phrase.

    The idea is that you want to see what genes are expressed to greater and lesser extents to work out the genetic mechanisms for metabolism and resistance.

    Although its a powerful tool and tells us a lot about what is actually going on genetically it usually encompasses less than 5% of the total genome of an organism. The study I would like to see are differential display or DD to cover bedbugs from the same colony both exposed to various insecticides and a control group of non exposed. Sadly DD when I last used it was a devilishly complex protocol and not many people seemed to get good reproducible results which is why in the late 90's it used to cost tens of thousands to get an experiment run.

    Each step is a step in the right direction though.

    David Cain
    Bed Bugs Limited

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  3. Richard_Naylor

    Joined: Sep '10
    Posts: 238


    Posted 8 years ago
    Tue Jan 25 2011 11:53:33

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    So in a nut shell, pesticide resistant bedbugs switched on their pesticide-resistance genes in response to...wait for it...pesticides!

    Not that surprising really but as you say David, each step is a step in the right direction (unless you are facing the wrong way! )

  4. victimized

    new username: help_me
    Joined: Nov '10
    Posts: 305


    Posted 8 years ago
    Tue Jan 25 2011 20:09:43

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    We need to kill them from the inside out. What we need, is to study the molecular make-up of their reproductive systems and find something that once in their body would make them infertile that we can ingest. Once in our bloodstream and they ingest our blood they would not be able to reproduce and eventually die off.
    Perhaps in conjunction with a residual treatment that overrides whatever defenses their bodies have created against pesticides would be good. Too bad I am not a science or math person.

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